El arcano de la quina (José Celestino Mutis, printed Madrid 1828)

The medical doctrine of cinchona written by José Celestino Mutis at Santa Fé de Bogotá, serialised in the city's newspaper from May 1793, and printed as a book at Madrid only in 1828, twenty years after his death. It sorts the bark into four official species with distinct uses, attacks the European habit of swallowing the crude bark, and arrives wrapped in an editor's prologue that dates the whole story and in notes that answer it with the new chemistry of quinine.